Forms & Other Documentation

Carotid Ultrasound

Cognitive Function Paper Tests

Scored Survey Forms

Raw Survey Forms

Protocols (with DOIs)

 

Scored Surveys

View Scoring Protocol

 

Cognitive Function

View Cognitive Function Protocol

 

Imaging (MRI)

 

    1. Anatomic Measures dx.doi.org/10.17504/protocols.io.n92ld5yw9v5b/v1
    2. Perfusion Arterial Spin Labeling dx.doi.org/10.17504/protocols.io.n92ld667xg5b/v1
    3. Diffusion Weighted Imaging dx.doi.org/10.17504/protocols.io.6qpvrkopolmk/v1
    4. White Matter Intensities dx.doi.org/10.17504/protocols.io.n2bvjebwngk5/v1
    5. Rest-State Resting-State Functional Magnetic Resonance Imaging dx.doi.org/10.17504/protocols.io.81wgbnp41gpk/v1

 

Labs & Biomarkers

 

    1. APOE4 genotyping [DOI]: dx.doi.org/10.17504/protocols.io.n92ldzo68v5b/v1
    2. Milliplex Assay [DOI]: dx.doi.org/10.17504/protocols.io.n2bvj8rkbgk5/v1
    3. AD Biomarkers [DOI]: dx.doi.org/10.17504/protocols.io.bp2l6dop5vqe/v1

Citation Policy
Data collection and sharing for the Precision Aging Network (PAN) is funded by the National Institute on Aging (National Institutes of Health Grant “Closing the Gap Between Cognitive Health Span and Human Lifespan” (U19AG065169)).
MindCrowd Data

MindCrowd® is a web-based cognitive testing platform hosted at The Translational Genomics Research Institute (TGen). Initially funded through TGen and private donors in 2013 it grew to over 800,000 users across the globe. MindCrowd® is Project 1 of the Precision Aging® Network grant and serves not only as an entryway to the Healthy Minds for Life (Project 2) study but also affords participants opportunities for other ancillary studies.

For purposes of sharing data, we are including complete case data on a set of demographics data (age, sex, race/ethnicity) and two scored cognitive function tests, the paired associates learning test and simple visual reaction time test (svRT or attention test). We also include other user-provided health information that is included at the time the cognitive function tests were taken (note these variables may contain missing information).

A manuscript that describes the history of MindCrowd® and Precision Aging® Network more broadly can be found in a Gerontology editorial (https://doi.org/10.1159/000548488).

This data are included in a single data table as an Excel file through the research portal.

  Available (N=364810)
Age 364810 (100%)
Sex 364810 (100%)
Race/Ethnicity 364810 (100%)
Handedness 357829 (98.1%)
Highest Level of Education Completed 363808 (99.7%)
Attention Test (svRT) 364810 (100%)
Paired Associates Test 364810 (100%)
Number of Daily Medications 357777 (98.1%)
No Chronic Conditions 277812 (76.2%)
Depression/Anxiety 277812 (76.2%)
Chronic Stress 277812 (76.2%)
Stroke 277812 (76.2%)
Alzheimers 277812 (76.2%)
Brain Disease 277812 (76.2%)
Loss of Consciousness 277812 (76.2%)
Memory Problems 277812 (76.2%)
Seizures 277812 (76.2%)
Parkinson’s Disease 277812 (76.2%)
Sleep Problems 277812 (76.2%)
Type I Diabetes 277812 (76.2%)
Type II Diabetes 277812 (76.2%)
Hypertension 277812 (76.2%)
Heart Disease 277812 (76.2%)
Smoking 277812 (76.2%)
Cancer 277812 (76.2%)

Data Dictionary

View MindCrowd Data Dictionary

Healthy Minds for Life Data

Healthy Minds for Life (HML) is the in-depth in-person longitudinal cohort project (Project 2) of the Precision Aging® Network. Data are collected from four sites: University of Arizona, Emory University, Johns Hopkins University and the University of Miami.

Many of the data collected in this study were summarized in a manuscript in Frontiers in Aging Neuroscience (https://doi.org/10.3389/fnagi.2019.00128). Additionally, manuscript that describes the history and details of the HML cohort and how it fits into the Precision Aging® Network more broadly we recommend a Gerontology editorial on the topic (https://doi.org/10.1159/000548488).

With the exception of the full MindCrowd® dataset, all data tables described on this website describe data from HML participants.

Healthy Minds for Life Demographics (HML)

There are many health history, medications, demographic and biometrics data that have been collected both online (through MindCrowd) and in at in-person visits (Healthy Minds for Life). Some demographics (like age) are different from these two demographics tables because of the time between online sign-up to MindCrowd and recruitment into Healthy Minds for Life, we suggest using Healthy Minds for Life demographics (age, sex, etc.) as these are the closest in time to other data collected in person.

  1. Healthy Minds for Life Demographics
  2. Healthy Minds for Life Eligibility
  3. Medications and Health Intake
  4. Mind Crowd Demographics (includes some health history variables)
  5. Biometrics Data
  Available (N=764)
Age 764 (100%)
Sex 764 (100%)
Race/Ethnicity 764 (100%)
Handedness 758 (99.2%)
Highest Level of Education Completed 764 (100%)
Attention Test (svRT) 764 (100%)
Paired Associates Test 764 (100%)
Number of Daily Medications 753 (98.6%)
Health Intake 764 (100%)
Mind Crowd Demographics (includes some health history variables) 726 (95.0%)
Medications and Health Intake 764 (100%)
Biometrics Data 763 (99.9%)
Healthy Minds for Life Eligibility 764 (100%)

These data can be found in the HML Demographics, HML Eligibility, Health Intake, MindCrowd Demographics, and Biometrics

Data Dictionary

View the HML Demographics Data Dictionary

Note: The Health Intake data table contains information about medications. We created a variable “dsc_meds_label_1” which is a derived variable using “hif_meds_1” variable and “hif_meds_oth_1” variable that should be used when the “meds_label_1” is missing.

Carotid Ultrasound

Each of the 4 sites was equipped with a Terason uSmart 3300 NexGen Ultrasound system with a 15L4A MHz uSmart Linear Array Transducer or alternative ultrasound systems with a 10-15MHz linear array transducer and a pre-set vascular protocol.

The mean and maximum intima-media thickness (IMT) of the near and the far walls of both right and left common carotid, carotid bifurcation, and internal carotid arteries are measured in the plaque-free segments. Doppler was used for measuring blood flow velocities in examination performed on the right and left common carotid, (CCA) internal (ICA) and external carotid arteries (ECA) for quick assessment of general extracranial hemodynamic status.

These data are located in the Carotid Ultrasound data table

  Available (N=764)
Velocity Data 288 (37.7%)
Intima-Media Thickness (IMT) Data 194 (25.39%)

Standard Operating Procedures

Data Dictionary

View Carotid Ultrasound Data Dictionary

Cognitive Function

There are 4 paper scored tests and 5 computer captured cognitive tests.

Paper Tests

  1. Rey Auditory Verbal Learning Test (AVLT)
  2. Montreal Cognitive Assessment (MoCA)
  3. North American Adult Reading Test (NAART) Instructions
  4. North American Adult Reading Test (NAART) Answer Key
  5. Patient Health Questionnaire-9 (PHQ-9)

Online Tests

  1. Verbal Paired Associate Learning (associative memory)
  2. Simple and Choice Reaction Time (information processing speed)

Three are executive functioning tasks

  1. Keep Track Task (updating/working memory)
  2. Flanker Task (inhibition)
  3. Letter Number Task (set shifting)
[Protocol: dx.doi.org/10.17504/protocols.io.14egnyqw6v5d/v1]

Participant level results from these tests can be found in data tables with the test names.

  Available (N=764)
AVLT 763 (99.87%)
MoCA 762 (99.74%)
NAART 762 (99.74%)
PHQ-9* 763 (99.87%)
Flanker Task 653 (85.5%)
Keep Track Task 587 (76.8%)
Letter Number Task 598 (78.3%)
Simple and Choice Reaction Time 618 (80.9%)
Verbal Paired Associate Learning 631 (82.6%)
*PHQ-9 is a depression screening tool

Data Dictionary

View Cognitive Function Data Dictionary

Imaging (MRI)

There are 7 data tables with processed MRI data.

  1. Anatomic Measures (using freesurfer)
  2. Perfusion Arterial Spin Labeling
  3. Diffusion Weighted Imaging
  4. Resting-State Functional Magnetic Resonance Imaging Cortical-Cerebellar
  5. Resting-State Functional Magnetic Resonance Imaging Whole Brain
  6. Resting-State Functional Magnetic Resonance Imaging Intra-Regional
  7. White Matter Hyperintensities
  Available (N=764)
Anatomic Measures 700 (91.6%)
Perfusion Arterial Spin Labeling 671 (87.8%)
Diffusion Weighted Imaging 671 (87.8%)
Resting-State Functional Magnetic Resonance Imaging
Cortical-Cerebellar		 672 (88%)
Resting-State Functional Magnetic Resonance Imaging Whole
Brain		 672 (88%)
Resting-State Functional Magnetic Resonance Imaging
Intra-Regional		 672 (88%)
White Matter Hyperintensities 692 (90.6%)

The data tables for these data can be found here (in order): MRI Anatomic Measures; MRI Perfusion ASL; MRI Diffusion Imaging; Resting State fMRI corticocereb; Resting State fMRI wholebrain; Resting State fMRI; and White Matter Hyperintensities

Data Dictionary

View the Imaging (MRI) Data Dictionary

Protocols

There are 5 protocols associated with these data

  1. Anatomic Measures dx.doi.org/10.17504/protocols.io.n92ld5yw9v5b/v1
  2. Perfusion Arterial Spin Labeling dx.doi.org/10.17504/protocols.io.n92ld667xg5b/v1
  3. Diffusion Weighted Imaging dx.doi.org/10.17504/protocols.io.6qpvrkopolmk/v1
  4. White Matter Intensities dx.doi.org/10.17504/protocols.io.n2bvjebwngk5/v1
  5. Rest-State Resting-State Functional Magnetic Resonance Imaging dx.doi.org/10.17504/protocols.io.81wgbnp41gpk/v1
Labs & Biomarkers

Currently we have 7 data tables containing labs and biomarkers:

  1. DNA methylation: Horvath, Altum, and DunedinPACE clocks
  2. TaqMan APOE4 genotyping for SNPs rs7412 and rs429358
  3. Polygenetic Risk Scores
  4. MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A – Immunology Multiplex Assay
  5. AD Biomarkers (Simoa Neuro 4-Plex E and Human pTau-181 Assays)
  6. Blood Chemistry (Sonora Quest Laboratory)
  7. NULISAseq Disease Panel 1
  Available (N=764)
AD Plasma Biomarkers 628 (82.2%)
APOE4 Status 445 (58.25%)
Epigenetic Clocks 428 (56.02%)
Millipore Cytokine Assay 661 (86.52%)
NULISA Seq CNS Disease Panel 569 (74.48%)
Polygenic Risk Scores 445 (58.25%)
Sonora Quest Blood Chemistries 645 (84.42%)

Data tables include Epigenetic Clocks, APOE4, Polygenetic Risk Scores, Millipore Cytokine Assay, AD Plasma Biomarkers, Sonora Quest Blood Chemistries, and NULISAseq

Data Dictionary

View the Labs & Biomarkers Data Dictionary

Protocols

There are 3 protocols associated with these assays

  1. APOE4 genotyping [DOI]: dx.doi.org/10.17504/protocols.io.n92ldzo68v5b/v1
  2. Milliplex Assay [DOI]: dx.doi.org/10.17504/protocols.io.n2bvj8rkbgk5/v1
  3. AD Biomarkers [DOI]: dx.doi.org/10.17504/protocols.io.bp2l6dop5vqe/v1
Non-Invasive Technologies

These data are captured using non-invasive technology (sound, video, sweat and wearable devices). The processing of these data typically involves machine learning and novel techniques.

There are 4 categories of data

  1. Cortisol (palmer sweat Direct Analysis in Real Time Mass Spectrometry (DART-MS))
  2. Sensor/Wearable (Garmin)
  3. Frailty (Upper Extremity Function, video)
  4. Language and Speech Tasks (sound files)
  Available (N=764)
Garmin 439 (57.46%)
Language Speech Task 753 (98.56%)
UEF Frailty 687 (89.92%)
Cortisol 607 (79.45%)

These data are found in the Cortisol, LabFront Garmin, UEF Frailty, and Language Speech Task data tables

Data Dictionary

View Wearables Data Dictionary

Surveys

Scored Surveys

There are a total of 15 surveys, with 7 scored instruments

Data collection forms for the scored surveys are included in the Scoring Protocol.

Scored Survey Forms

  Available (N=764)
Anxiety 568 (74.3%)
QPAR 566 (74.1%)
SWLS 616 (80.6%)
Sleep 564 (73.8%)
Social Stressors 604 (79.1%)
Social Support 611 (80%)
Stress 616 (80.6%)
[Scoring Protocol here DOI: dx.doi.org/10.17504/protocols.io.q26g7nwy9lwz/v1]

These surveys are included in the HML Scored Survey data table and raw data for these surveys can be found in the data tables named like: Perceived Stress Raw Data

Data Dictionary (Scored Surveys)

View the Scored Surveys Data Dictionary

Remaining surveys are participant reported and can be found in the data tables with the following names:

  • Socioeconomic Survey
  • Subjective English Survey
  • Health Medical Survey
  • Family History Survey
  • Diet Survey
  • Covid Survey
  • Brain Disease Survey
  • ADL Survey

Raw Surveys

  Available (N=764)
ADL 610 (79.8%)
Anxiety 568 (74.3%)
Brain Disease 557 (72.9%)
Covid 557 (72.9%)
Diet 609 (79.7%)
FHAD 627 (82.1%)
Health Medical 558 (73%)
QPAR 566 (74.1%)
SES 619 (81%)
SWLS 616 (80.6%)
Sleep 564 (73.8%)
Social Stressors 604 (79.1%)
Social Support 611 (80%)
Stress 616 (80.6%)
Subjective English 638 (83.5%)

Data Dictionary (Raw Surveys)

View the Raw Surveys Data Dictionary

Survey Forms (Raw Data)

Forms & Other Documentation

Carotid Ultrasound

Cognitive Function Paper Tests

Scored Survey Forms

Raw Survey Forms

Protocols (with DOIs)

 

Scored Surveys

View Scoring Protocol

 

Cognitive Function

View Cognitive Function Protocol

 

Imaging (MRI)

 

    1. Anatomic Measures dx.doi.org/10.17504/protocols.io.n92ld5yw9v5b/v1
    2. Perfusion Arterial Spin Labeling dx.doi.org/10.17504/protocols.io.n92ld667xg5b/v1
    3. Diffusion Weighted Imaging dx.doi.org/10.17504/protocols.io.6qpvrkopolmk/v1
    4. White Matter Intensities dx.doi.org/10.17504/protocols.io.n2bvjebwngk5/v1
    5. Rest-State Resting-State Functional Magnetic Resonance Imaging dx.doi.org/10.17504/protocols.io.81wgbnp41gpk/v1

 

Labs & Biomarkers

 

    1. APOE4 genotyping [DOI]: dx.doi.org/10.17504/protocols.io.n92ldzo68v5b/v1
    2. Milliplex Assay [DOI]: dx.doi.org/10.17504/protocols.io.n2bvj8rkbgk5/v1
    3. AD Biomarkers [DOI]: dx.doi.org/10.17504/protocols.io.bp2l6dop5vqe/v1