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PAN Related Findings

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Alzheimer’s Disease
 & Neurodegeneration

  • The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration.
  • Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer’s Disease.
  • NMDA Receptor-Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer’s Disease.
  • Assessing brain and biological aging trajectories associated with Alzheimer’s disease.
  • Single-Cell Patch-Clamp/Proteomics of Human Alzheimer’s Disease iPSC-Derived Excitatory Neurons Versus Isogenic Wild-Type Controls Suggests Novel Causation and Therapeutic Targets.
  • Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer’s Disease-Related Biomarkers.
  • Exploring the genetic heterogeneity of Alzheimer’s disease: Evidence for genetic subtypes.
  • Diffusion model enables quantitative CBF analysis of Alzheimer’s Disease.
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Biomedical Research &
 Machine Learning

  • Rule-Enhanced Active Learning for Semi-Automated Weak Supervision.
  • A Comprehensive Evaluation of Biomedical Entity Linking Models.
  • SeizFt: Interpretable Machine Learning for Seizure Detection Using Wearables.
  • Optimizations for Computing Relatedness in Biomedical Heterogeneous Information Networks: SemNet 2.0.
  • Data Augmentation with Cross-Modal Variational Autoencoders (DACMVA) for Cancer Survival Prediction.
  • CompositeView: A Network-Based Visualization Tool.
  • BioSift: A Dataset for Filtering Biomedical Abstracts for Drug Repurposing and Clinical Meta-Analysis.
  • sEBM: Scaling Event Based Models to Predict Disease Progression via Implicit Biomarker Selection and Clustering
  • Predicting Working Memory in Healthy Older Adults Using Real-Life Language and Social Context Information: A Machine Learning Approach
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Aging & Longevity

  • Consensus Paper: Cerebellum and Ageing.
  • Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds.
  • Does Modulation of an Epigenetic Clock Define a Geroprotector?
  • The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank.
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Genetics & Personalized Medicine

  • Exploring human biology with N-of-1 clinical trials.
  • Accommodating Serial Correlation and Sequential Design Elements in Personalized Studies and Aggregated Personalized Studies.
  • A time-series analysis of blood-based biomarkers within a 25-year longitudinal dolphin cohort.
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Mental Health & 
Cognitive Resilience

  • Can we promote cognitive resilience in late-life depression?
  • Elevated frequency and everyday functioning implications of vascular depression in persons with HIV disease.
  • Implications of Vascular Depression for Successful Cognitive Aging in HIV disease.
  • Association of white matter hyperintensities and clinical vascular burden with depressive symptoms in Black older adults.
  • Validity of the NIH toolbox cognitive battery in a healthy oldest-old 85+ sample.
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Computational Biology 
& Bioinformatics

  • Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson’s Disease.
  • Cross-Domain Text Mining of Pathophysiological Processes Associated with Diabetic Kidney Disease.
  • A Distribution-Free Model for Longitudinal Metagenomic Count Data.
  • Interrogating the Human Diplome: Computational Methods, Emerging Applications, and Challenges
  • NISC: Neural Network-Imputation for Single-Cell RNA Sequencing and Cell Type Clustering
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Neurological Disorders
 & Cognitive Function

  • Comparing therapeutic modulators of the SOD1 G93A Amyotrophic Lateral Sclerosis mouse pathophysiology.
  • What Threshold of Amyloid Reduction Is Necessary to Meaningfully Improve Cognitive Function in Transgenic Alzheimer’s Disease Mice?
  • Associations Between Vascular Risk Factors and Perivascular Spaces in Adults with Intact Cognition, Mild Cognitive Impairment, and Dementia.
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Speech, Language
 & Cognitive Decline

  • When I am sixty-four… evaluating language markers of well-being in healthy aging narratives.
  • Harnessing Speech-Derived Digital Biomarkers to Detect and Quantify Cognitive Decline Severity in Older Adults.
  • How ready is speech-to-text for psychological language research? Evaluating the validity of AI-generated English transcripts for analyzing free-spoken responses in younger and older adults.
  • Neuroimaging and verbal memory assessment in healthy aging adults using a portable low-field MRI scanner and a web-based platform.

News & Information

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Past Newsletters

Awareness Months

American Diabetes Month

American Diabetes Month

November 12, 2025

November is National Diabetes Month, a time when communities...

National Family Caregiver’s Month

National Family Caregiver’s Month

November 10, 2025

By: Carol W. Cecil, MAEd., Public Health Advisor, Office of...

10 Holiday Tips for Family Caregivers

10 Holiday Tips for Family Caregivers

December 16, 2024

Holidays are upon us bringing not only joy and laughter...

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